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樹突狀細胞在腫瘤抗原的表達中起著關(guān)鍵作用,能啟動天然和適應(yīng)性免疫反應(yīng)。而腫瘤微環(huán)境(Tumor Microenvironment,TME)包含抑制樹突狀細胞分化和成熟的免疫抑制因子網(wǎng)絡(luò)。免疫佐劑一直專注于調(diào)節(jié)樹突狀細胞的功能,以改善癌癥免疫治療。最近,澳門大學健康科學學院癌癥中心和轉(zhuǎn)化醫(yī)學研究所團隊在期刊《Nano Today》(IF=20.722)上發(fā)表題為“Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy."的文章,研究通過metal-phenolic coordination自組裝聲敏聚合物(PEG-b-IR)、谷胱甘肽抑制劑(sabutoclax)、Mn2+和TME酸敏酚聚合物(PEG-b-Pho),研制出了一種phenolic 納米佐劑。該佐劑展示了SDT介導的ICD效應(yīng)和Mn2+的聯(lián)合作用促進了cGAS-STING通路的激活,顯著促進了樹突狀細胞的成熟。此外,這種phenolic納米佐劑使腫瘤對PD-L1檢查點阻斷免疫療法高度敏感,從而有效抑制遠處腫瘤的生長并抑制肺轉(zhuǎn)移,為增強的癌癥免疫療法提供了彌補抗腫瘤免疫不足的治療局限性的潛力。
本文中使用了欣博盛Mouse IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, and IFN-β ELISA kits檢測了血清樣本中這些細胞因子的表達量。
1.文章題目:Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy.
期 刊:Nano Today(影響因子:20.722)
發(fā)表時間:25 January 2022
作 者:Tian H, Wang G, Sang W, et al.
作者單位:澳門大學健康科學學院癌癥中心和轉(zhuǎn)化醫(yī)學研究所
使用產(chǎn)品:Mouse IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, and IFN-β ELISA kits
2.文章題目:Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
期 刊:Signal Transduction and Targeted Therapy(影響因子:18.187)
發(fā)表時間:20 January 2022
作 者:Wang Z, Zeng F, Hu Y, et al.
作者單位:四川大學華西醫(yī)學院
使用產(chǎn)品:Mouse MCP-1, IL-6, TNF-α , KC, IFN-γ, CXCL2 ELISA kit
樣本類型:結(jié)腸組織
3.文章題目:Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion.
期 刊:Journal of Experimental Medicine(影響因子:14.307)
發(fā)表時間:21 January 2022
作 者:Cai Y, Wang Y, Shi C, et al.
作者單位:深圳大學醫(yī)學院
使用產(chǎn)品:Human Granzyme B ELISA kit
4.文章題目:Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer.
期 刊:Theranostics(影響因子:11.556)
發(fā)表時間:1 January 2022
作 者:Li X, Sun Z, Peng G, et al.
作者單位:中國醫(yī)學科學院基礎(chǔ)醫(yī)學研究所
使用產(chǎn)品:goat anti-rabbit IgG (H+L)-HRP
5.文章題目:Dual-function injectable fibrin gel incorporated with sulfated chitosan nanoparticles for rhBMP-2-induced bone regeneration.
期 刊:Applied Materials Today(影響因子:10.041)
發(fā)表時間:5 January 2022
作 者:Chen X, Wang S, Zhang X, et al
作者單位:華東理工大學
使用產(chǎn)品:Mouse IL-1β, IL-4, IL-6, IL-10, TNFα, TGF-β1 ELISA kits
6.文章題目:Engineered Mesenchymal Stem Cells as a Biotherapy Platform for Targeted Photodynamic Immunotherapy of Breast Cancer.
期 刊:Advanced Healthcare Materials(影響因子:9.933)
發(fā)表時間:03 January 2022
作 者:Zhang H, Feng Y, Xie X, et al.
作者單位:中國電子科技大學生命科學與技術(shù)學院
使用產(chǎn)品:Mouse IL-12P70,IFN-γ and TNF-α ELISA kits
7.文章題目:Construction of novel antiplatelet modified polyethersulfone membrane and study into its blood compatibility
期 刊:Materials Science and Engineering:C(影響因子:7.328)
發(fā)表時間:13 January 2022
作 者:Fu X, Lei T, Li S, et al.
作者單位: 中南大學
使用產(chǎn)品:Human IL-6, TNF-α, IL-10 ELISA kits
8.文章題目:Delivery of nVEGFi using AAV8 for the treatment of neovascular age-related macular degeneration
期 刊:Molecular Therapy-Methods & Clinical Development(影響因子:6.698)
發(fā)表時間:10 January 2022.
作 者:She K, Su J, Wang Q, et al.
作者單位:四川大學華西醫(yī)院
使用產(chǎn)品:TMB底物
9.文章題目:PINK1 Kinase Enhances the Repair Effects of Bone Marrow Mesenchymal Stem Cells on Renal Ischemia/Reperfusion-Induced Acute Kidney Injury in Mice.
期 刊:Stem Cell Research & Therapy(影響因子:6.832)
發(fā)表時間:12 January 2022
作 者:Lin C, Chen W, Han Y, et al.
作者單位:河北北方大學基礎(chǔ)醫(yī)學院
使用產(chǎn)品:Mouse IL-10,TNF-α ELISA kits
10.文章題目: Superparamagnetic Iron Oxide Nanoparticles Protect Human Gingival Fibroblasts from Porphyromonas gingivalis Invasion and Inflammatory Stimulation
期 刊:International Journal of Nanomedicine(影響因子:6.4)
發(fā)表時間:6 January 2022
作 者:Chen Y, Zhang Q, Qin X, et al.
作者單位:南京醫(yī)科大學
使用產(chǎn)品:Human IL-1β, IL-6, IL-8, TNF-α ELISA kits
11.文章題目: Effects of polysaccharides from Fuzhuan brick tea on immune function and gut microbiota of cyclophosphamide-treated mice
期 刊:The Journal of Nutritional Biochemistry(影響因子:6.048)
發(fā)表時間:10 January 2022.
作 者:Bai Y, Zeng Z, Xie Z, et al
作者單位:南京農(nóng)業(yè)大學食品科學與技術(shù)學院
使用產(chǎn)品:Mouse TNF-α, IFN-γ and IgA ELISA kits
12.文章題目:Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway.
期 刊:Phytotherapy Research(影響因子:5.878)
發(fā)表時間:25 January 2022
作 者:Li G, Duan L, Yang F, et al.
作者單位:蘭州大學第二醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6, TNF-α ELISA kits
樣本類型:腦組織
13.文章題目:Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways.
期 刊:Biochemical Pharmacology(影響因子:5.858)
發(fā)表時間:12 January 2022
作 者:Tu Y, Tan L, Lu T, et al
作者單位:澳門大學粵港澳中醫(yī)藥及免疫疾病研究聯(lián)合實驗室
使用產(chǎn)品:Human IL-8, MMP-1 ELISA kits
14.文章題目: An eco-friendly zein nanoparticle as robust cosmetic ingredient ameliorates skin photoaging
期 刊:Industrial Crops and Products(影響因子:5.645)
發(fā)表時間:11 January 2022
作 者:Zhu J J, Huang X N, Yang T, et al.
作者單位:華南理工大學
使用產(chǎn)品:Human TNF-α、IL-6 ELISA kit
15.文章題目:Yindan Jiedu granules exhibit anti-inflammatory effect in patients with novel Coronavirus disease (COVID,-,19) by suppressing the NF-κB signaling pathway.
期 刊:Phytomedicine(影響因子:5.34)
發(fā)表時間:10 January 2022
作 者:Feng Y, Zhu B, Liu Y, et al.
作者單位: 首都醫(yī)科大學北京地壇醫(yī)院
使用產(chǎn)品:Mouse TNF-α,IL-6,IL-1β ELISA kits
16.文章題目:Preventive effects of traditional Chinese medicine formula Huoxiangzhengqi against lipopolysaccharides-induced inflammatory response.
期 刊:Phytomedicine(影響因子:5.34)
發(fā)表時間:29 January 2022
作 者:Gao M, Zou Z, Qiu Y, et al.
作者單位:重慶醫(yī)科大學公共衛(wèi)生與管理學院
使用產(chǎn)品:Mouse IL-6 ELISA kits
17.文章題目:Interactions Between Streptococcus gordonii and Fusobacterium nucleatum Altered Bacterial Transcriptional Profiling and Attenuated the Immune Responses of Macrophages
期 刊:Frontiers in Cellular and Infection Microbiology(影響因子:5.293)
發(fā)表時間:07 January 2022
作 者:Liu T, Yang R, Zhou J, et al.
作者單位:中山大學光華口腔醫(yī)學院口腔醫(yī)院
使用產(chǎn)品:Human IL-1β, IL-6, TNF-α ELISA kits
18.文章題目:Discovery of Novel 2-Aryl-4-Bis-amide Imidazoles (ABAI) As Anti-inflammatory Agents for the Treatment of Inflammatory Bowel Diseases (IBD)
期 刊:Bioorganic Chemistry(影響因子:5.275)
發(fā)表時間:20 January 2022
作 者:Li L, Yuan S, Lin L, et al.
作者單位:南方醫(yī)科大學
使用產(chǎn)品:Human IL-6 ,IL-1β, ELISA Kits
19.文章題目: Isothermal RNA Amplification for the Detection of Viable Pathogenic Bacteria to Estimate the Salmonella Virulence for Causing Enteritis.
期 刊:Journal of Agricultural and Food Chemistry(影響因子:5.273)
發(fā)表時間:31 January 2022
作 者:Xue T, Lu Y, Yang H, et al.
作者單位: 四川大學華西醫(yī)院
使用產(chǎn)品:Mouse IL-6, IFN-γ ELISA kits
20.文章題目:Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis期 刊:Cell Death Discovery(影響因子:5.241)
發(fā)表時間:17 January 2022
作 者:Li G, Lin Y, Zhang Y, et al.
作者單位:上海交通大學醫(yī)學院
使用產(chǎn)品:Human VEGF, IL-8 ELISA kits
21.文章題目:Preparation, chemical structure, and immunostimulatory activity of a water-soluble heteropolysaccharide from Suillus granulatus fruiting bodies
期 刊: Food Chemistry: X(影響因子:5.182)
發(fā)表時間:15 January 2022
作 者:Gao X, Zeng R, Ho C T, et al.
作者單位:廣東省科學院微生物研究所
使用產(chǎn)品:Mouse TNF-α、IL-6、MCP-1 ELISA kits
22.文章題目:Dendrobium officinale Leaf Polysaccharides Ameliorated Hyperglycemia and Promoted Gut Bacterial Associated SCFAs to Alleviate Type 2 Diabetes in Adult Mice
期 刊: Food Chemistry: X(影響因子:5.182)
發(fā)表時間:10 January 2022.
作 者: Fang J, Lin Y, Xie H, et al.
作者單位:浙江工業(yè)大學食品科學與技術(shù)系
使用產(chǎn)品:Mouse IL-6, TNF-α ELISA kits
樣本類型:肝臟和結(jié)腸組織
23.文章題目:Cytosporone B (Csn-B), an NR4A1 agonist, attenuates acute cardiac allograft rejection by inducing differential apoptosis of CD4+ T cells
期 刊:International Immunopharmacology(影響因子:4.932)
發(fā)表時間:10 January 2022.
作 者:Ding X, Le S, Wang K, et al.
作者單位:武漢大學
使用產(chǎn)品:Mouse IL-17A ELISA kits
24.文章題目:HSP60 regulates the cigarette smoke-induced activation of TLR4-NF-κB-MyD88 signalling pathway and NLRP3 inflammasome
期 刊:International immunopharmacology(影響因子:4.932)
發(fā)表時間:5 January 2022.
作 者:Ou G, Zhu M, Huang Y, et al.
作者單位:四川遂寧遂寧市中心醫(yī)院
使用產(chǎn)品:Mouse IL-1β, TNF-α, and IL-6 ELISA kits
25.文章題目:MiR-124-3p targeting PDE4B attenuates LPS-induced ALI through the TLR4/NF-κB signaling pathway.
期 刊:International Immunopharmacology(影響因子:4.932)
發(fā)表時間:18 January 2022.
作 者:Zhou Q, He D X, Deng Y L, et al.
作者單位: 四川大學華西醫(yī)院
使用產(chǎn)品:Mouse IL-1β,TNF-α ELISA kits
26.文章題目:PD-1 inhibitor causes pathological injury to multiple organs in a Lewis lung cancer mouse model.
期 刊: International Immunopharmacology(影響因子:4.932)
發(fā)表時間:22 January 2022
作 者:Chen Y, Liu Y, Xiong X, et al.
作者單位:南昌大學第二附屬醫(yī)院
使用產(chǎn)品:Mouse IL-1β, IL-6, and TNF-α ELISA kits
27.文章題目:Characterization and Evaluation of Antioxidant and Anti-Inflammatory Activities of Flavonoids from the Fruits of Lycium barbarum.
期 刊:Foods(影響因子:4.35)
發(fā)表時間:24 January 2022
作 者:Yang T, Hu Y, Yan Y, et al.
作者單位:南京農(nóng)業(yè)大學食品科學與技術(shù)學院
使用產(chǎn)品:Mouse TNF-α, IL-1β, IL-6 ELISA kits
28.文章題目:Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF-β/SMAD signaling.
期 刊:Authorea Preprints(影響因子:4.335)
發(fā)表時間:January 12, 2022
作 者:Yin W, Wu W, Jiao H, et al.
作者單位:南京大學
使用產(chǎn)品:Human Alpha Fetoprotein (AFP) ELISA kit
29.文章題目:Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3
期 刊:Environmental Toxicology(影響因子:4.119)
發(fā)表時間:21 January 2022
作 者:Liu F, Cheng X, Wu S, et al.
作者單位:浙江大學
使用產(chǎn)品:Human TNFα, IL-6 and IL-1β ELISA kits
30.文章題目:Antigenic and immunogenic properties of recombinant proteins consisting of two immunodominant African swine fever virus proteins fused with bacterial lipoprotein OprI
期 刊:Virology Journal (影響因子:4.099)
發(fā)表時間:21 January 2022
作 者:Zhang G, Liu W, Gao Z, et al.
作者單位:中國農(nóng)業(yè)科學院蘭州獸醫(yī)研究所
使用產(chǎn)品:Mouse IL-2, IFN-γ, TNF-α ELISA kits
31.文章題目:Platelet protects angiotensin II-driven abdominal aortic aneurysm formation through inhibition of inflammation
期 刊:Experimental Gerontology(影響因子:4.032)
發(fā)表時間:14 January 2022.
作 者:Liu X, Chen X, Xu C, et al.
作者單位:杭州市浙江醫(yī)院心內(nèi)科
使用產(chǎn)品:Mouse TNF-α, IL-1β, and IL-6 ELISA kits
32.文章題目: Anti‐diabetic and gut microbiota modulation effects of sacha inchi (Plukenetia volubilis L.) leaf extract in streptozotocin‐induced type 1 diabetic mice
期 刊:Journal of the Science of Food and Agriculture(影響因子:3.638)
發(fā)表時間:19 January 2022
作 者:Lin J, Wen J, Xiao N, et al.
作者單位:華南農(nóng)業(yè)大學食品學院
使用產(chǎn)品:Human insulin ELISA kits
33.文章題目: Immunological Risk Assessment of Xenogeneic Dural Patch by Comparing with Raw Material via GTKO Mice
期 刊: BioMed Research International(影響因子:3.411)
發(fā)表時間:17 January 2022
作 者:Mu Y, Shao A, Shi L, et al.
作者單位:西南交通大學材料科學與工程學院
使用產(chǎn)品:Mouse IgG、IgM ELISA kits
34.文章題目: FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells
期 刊:Military Medical Research(影響因子:3.329)
發(fā)表時間:29 January 2022
作 者:Tan Y Y, Zhou H Q, Lin Y J, et al.
作者單位:中山大學附屬第五醫(yī)院
使用產(chǎn)品:BSA
35.文章題目:Loss of JNK-Associated Leucine Zipper Protein Promotes Peritoneal Dialysis-Related Peritoneal Fibrosis
期 刊: Kidney Diseases (影響因子:3.222)
發(fā)表時間:1 January 2022
作 者:Tian M, Zhang L, Wang Y, et al.
作者單位:武漢大學人民醫(yī)院
使用產(chǎn)品:Human TGF-β1 ELISA kit
36.文章題目: Inflammatory level under different p53 mutation status and the regulation role of curcumin in tumor microenvironment.
期 刊: Immunobiology,(影響因子:3.144)
發(fā)表時間:7 January 2022.
作 者:Xu L, Xie X, Li X, et al.
作者單位:昆明理工大學生命科學與技術(shù)學院
使用產(chǎn)品:Human IL6 ,M- CSF ELISA kits
37.文章題目:FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA
期 刊:Molecular Medicine Reports(影響因子:2.952)
發(fā)表時間:21 January 2022
作 者:Yang B, Liu D, Ren Y Q, et al.
作者單位:山西醫(yī)科大學第一醫(yī)院
使用產(chǎn)品:Human VEGF ELISA kits
38.文章題目: The recombinant pseudorabies virus expressing porcine deltacoronavirus spike protein is safe and effective for mice
期 刊:BMC veterinary research(影響因子:2.741)
發(fā)表時間:04 January 2022
作 者:Huang Y, Xu Z, Gu S, et al.
作者單位:四川農(nóng)業(yè)大學獸醫(yī)學院
使用產(chǎn)品:Mouse IL-4, IFN-γ ELISA kits
39.文章題目:Long Non-coding RNA GAS5/miR-520-3p/SOCS3 Axis Regulates Inflammatory Response in Lipopolysaccharide-Induced Macrophages.
期 刊:Biochemical Genetics(影響因子:1.89)
發(fā)表時間:31 January 2022
作 者:Du J, Jiang H, Wang B.
作者單位:長江大學第二臨床醫(yī)學院
使用產(chǎn)品:Human IL-6, IL-1β, and TNF-α ELISA kits
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