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BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α

更新時(shí)間：2023-05-17   點(diǎn)擊次數(shù)：403次

BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α

 

產(chǎn)品描述：

BioXcell InVivoPlus anti-mouse CD8α克隆號(hào)YTS 169.4單克隆抗體能與小鼠CD8α反應(yīng)。CD8抗原是一種跨膜糖蛋白，作為T(mén)細(xì)胞受體的共受體。與TCR一樣，CD8與抗原呈遞細(xì)胞(APC)展示的I類(lèi)MHC分子結(jié)合。CD8主要在細(xì)胞毒性T細(xì)胞表面表達(dá)，但也可在胸腺細(xì)胞、自然殺傷細(xì)胞和一些樹(shù)突狀細(xì)胞亞群中發(fā)現(xiàn)。CD8最常見(jiàn)的存在形式是由一個(gè)CD8α和一個(gè)CD8β鏈組成的異二聚體，然而，它也可以是由兩個(gè)CD8α鏈組成的同二聚體。CD8α和CD8β鏈均與免疫球蛋白可變輕鏈具有顯著同源性。每個(gè)CD8鏈的分子量約為34 kDa。BioXcell InVivoPlus anti-mouse CD8α克隆號(hào)YTS 169.4抗體在體內(nèi)使用時(shí)顯示出depleting活性。


BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α 

產(chǎn)品詳情：


產(chǎn)品名稱(chēng)

InVivoPlus anti-mouse CD8α

產(chǎn)品貨號(hào)

BP0117

產(chǎn)品規(guī)格

5/25/50/100mg

反應(yīng)種屬

Mouse

克隆號(hào)

YTS 169.4

同種型

Rat IgG2b, κ

免疫原

CBA mouse thymocytes

實(shí)驗(yàn)應(yīng)用

in vivo CD8+ T cell depletion
Western blot

產(chǎn)品形式

PBS, pH 7.0,Contains no stabilizers or preservatives

純度

>95%, Determined by SDS-PAGE

聚合

<5%, Determined by SEC

無(wú)菌處理

0.2 µm filtration

純化方式

Protein G

RRID

AB_10950145

分子量

150 kDa

小鼠病原檢測(cè)

Ectromelia/Mousepox Virus: Negative

Hantavirus: Negative

K Virus: Negative

Lactate Dehydrogenase-Elevating Virus: Negative

Lymphocytic Choriomeningitis virus: Negative

Mouse Adenovirus: Negative

Mouse Cytomegalovirus: Negative

Mouse Hepatitis Virus: Negative

Mouse Minute Virus: Negative

Mouse Norovirus: Negative

Mouse Parvovirus: Negative

Mouse Rotavirus: Negative

Mycoplasma Pulmonis: Negative

Pneumonia Virus of Mice: Negative

Polyoma Virus: Negative

Reovirus Screen: Negative

Sendai Virus: Negative

Theiler’s Murine Encephalomyelitis: Negative

保存條件

抗體原液保存在4°C，不能冷凍保存。

推薦同型對(duì)照

InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin（貨號(hào)BP0090）

推薦抗體稀釋液

InVivoPure pH 7.0 Dilution Buffer（貨號(hào)IP0070）



為什么選擇InVivoPlus抗體？

InVivoPlus級(jí)別的產(chǎn)品內(nèi)毒素含量更低，經(jīng)過(guò)多種實(shí)驗(yàn)驗(yàn)證，更適合用于體內(nèi)實(shí)驗(yàn)研究

BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α


 該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻(xiàn)引用：


應(yīng)用

文章

體內(nèi)CD8+T細(xì)胞耗竭

(in vivo CD8+ T cell depletion)

1. Vashist, N., et al. (2018). 'Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression' Front Immunol 9: 505.

2. Triplett, T. A., et al. (2018). 'Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme' Nat Biotechnol 36(8): 758-764.

3. Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity' Nature 521(7550): 99-104.

4. Burrack, K. S., et al. (2015). 'Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells' PLoS Pathog 11(10): e1005191.

5. Wensveen, F. M., et al. (2015). 'NK cells link obesity-induced adipose stress to inflammation and insulin resistance' Nat Immunol 16(4): 376-385.

6. Li, Z., et al. (2015). 'Pre-treatment of allogeneic bone marrow recipients with the CXCR4 antagonist AMD3100 transiently enhances hematopoietic chimerism without promoting donor-specific skin allograft tolerance' Transpl Immunol 33(2): 125-129.

 

 

BioXcell熱銷(xiāo)產(chǎn)品--InVivoPlus anti-mouse CD8α

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