DNA損傷酶聯(lián)免疫檢測試劑盒DNA damage ELISA kit—Enzo Life Sciences熱銷產(chǎn)品

——用于腫瘤、細胞凋亡和氧化應激研究中DNA損傷的快速檢測

細胞暴露于氧化和環(huán)境應激經(jīng)常導致基因組DNA的分解或氧化，評價基因組DNA完整性或評估氧化DNA存在的測定法經(jīng)常用作驗證凋亡或DNA損傷開始的手段。8-羥基-2 '-脫氧鳥苷(8-OHdG)是一種修飾的核苷堿基，是氧化DNA損傷和氧化應激的常用生物標志物。尿液中的8-OHdG及其類似物8-羥基鳥苷和8-羥基鳥嘌呤與許多退行性疾病有關。在許多疾病中，包括膀胱癌和前列腺癌，囊性纖維化，特應性皮炎和類風濕性關節(jié)炎中，已經(jīng)研究了ROS的相關性和使用8-OHdG作為氧化應激的生物標志物。帕金森氏病、阿爾茨海默氏病和亨廷頓氏病是神經(jīng)退行性疾病，被認為是由具有這些疾病遺傳傾向的人接觸神經(jīng)毒素引起的。氧化應激與這些疾病的發(fā)病機制有關，在多種神經(jīng)系統(tǒng)疾病中檢測到DNA損傷水平升高。

Enzo Life Sciences的DNA損傷酶聯(lián)免疫檢測試劑盒是一種快速靈敏的競爭法免疫檢測試劑盒，可用于檢測和定量尿液、血清和唾液樣品中的8-羥基-2 '-脫氧鳥苷(8- OHdG)。

產(chǎn)品特點

● 高靈敏度，可檢測低至1 ng/ml 8-OHdG

● 在多類型樣本中驗證并獲得可靠結果

● 優(yōu)于半定量Western blot分析的全定量檢測

● 無邊緣效應，每個試劑盒可檢測更多樣本

產(chǎn)品詳情

標準曲線示例

部分產(chǎn)品文獻引用

1. The Dietary Fermentable Fiber Inulin Alters the Intestinal Microbiome and Improves Chronic Kidney Disease Mineral-Bone Disorder in a Rat Model of CKD: A. Biruete, et al.; bioRxiv (2023) 

2. Octanoic Acid - An Insecticidal Metabolite of Conidiobolus coronatus (Entomopthorales) That Affects Two Majors Antifungal Protection Systems in Galleria mellonella (Lepidoptera): Cuticular Lipids and Hemocyte: A. Kaczmarek, et al.; Int. J. Mol. Sci. 23, 5204 (2022)

3. Wasp Venom Ameliorates Scopolamine-Induced Learning and Memory Impairment in Mice: J.H. Chae, et al.; Toxins 14, 256 (2022)

4. Arbutin protects brain against middle cerebral artery occlusion-reperfusion (MCAo/R) injury: M. Kumar, et al.; Biochem. Biophys. Res. Commun. 577, 52 (2021)

5. Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism: H.E. El-Horany, et al.; Arch. Physiol. Biochem. 126, 157 (2020), Application(s): Rat blood serum

6. Evaluation of Effectiveness of Ultraviolet Emitting Lamps on the Cutaneous Production of Vitamin D3: Relationship of the Lamps Vitamin D3 Producing Potential to the Production of 8-Hydroxy-2'-Deoxyguanosine and Nitric Oxide: A. Shirvani, et al.; Anticancer Res. 40, 565 (2020)

7. In Vivo Anti-Inflammatory Potential of Viscozyme®-Treated Jujube Fruit: Y. Kim, et al.; Foods 9, 1033 (2020), Application(s): Mouse Liver tissue homogenate

8. Inhibitory Effect of Steamed Soybean Wastewater Against DSS-Induced Intestinal Inflammation in Mice: S. Jeong, et al.; Foods 9, 954 (2020), Application(s): Quantification of 8-OHdG level in mouse plasma.

9. N-acetylcysteine (NAC), an anti-oxidant, does not improve bone mechanical properties in a rat model of progressive chronic kidney disease-mineral bone disorder: M.R. Allen, et al.; PLoS One 15, e0230379 (2020)

10. Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice: Y. Woo, et al.; Antioxidants (Basel) 9, 449 (2020), Application(s): Serum

11. Antioxidative effects of olive polyphenols compared to vitamin E in piglets fed a diet rich in N-3 PUFA: J. Leskovec, et al.; Animals (Basel) 9, 161 (2019), Application(s): ELISA using pig serum

12. MicroRNA-204-3p Attenuates High Glucose-Induced MPC5 Podocytes Apoptosis by Targeting Braykinin B2 Receptor: X. Han, et al.; Exp. Clin. Endocrinol. Diabetes 127, 387 (2019), Application(s): Mouse MPC5 podocyte lysates

13. Oxidative stress and mitochondrial responses to stress exposure suggest that king penguins are naturally equipped to resist stress: A. Stier, et al.; Sci. Rep. 9, 8545 (2019), Application(s): Penguin plasma and red blood cell lysate

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