The MB20-11 monoclonal antibody reacts with mouse CD20. CD20 is a B cell-specific 33-37 kDa transmembrane protein which is also known as B-lymphocyte antigen, B1, and Bp35. CD20 plays roles in intracellular calcium regulation and B cell activation and is critical for an optimal B cell immune response against T-independent antigens. CD20 is first expressed after the induction of CD19 together with IgM during the pre-B to immature B cell transition in the bone marrow. It’s expression then increases during maturation with almost all mature B cells expressing some level of CD20. However, CD20 is not expressed by plasma blasts or plasma cells. CD20 is expressed by most B cell neoplasms and is useful in diagnosing B cell lymphomas and leukemia. Many anti-CD20 monoclonal antibodies are currently being used to successfully treat leukemia, lymphomas, and various autoimmune diseases. A single injection of the MB20-11 antibody has been reported to deplete circulating B cells in mice within 1 hour of treatment, with a durable effect for 57 days before B cells begin to repopulate in the blood and spleen.

產(chǎn)品名稱:InVivoMAb anti-mouse CD20

反應(yīng)種屬:mouse

宿主來(lái)源:Mouse

實(shí)驗(yàn)應(yīng)用:in vivo B cell depletion, Western blot

同種型:IgG2c, κ

免疫原:Mouse CD20-GFP transfected 300.19 cells

克隆性:Monoclonal

克隆號(hào):MB20-11

產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml

保存溫度:Undiluted at 4°C in the dark

運(yùn)輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

預(yù)期分子量:150 kDa

產(chǎn)品形式:液體

有效期:One year from the date of receipt if stored as recommended

產(chǎn)地:美國(guó)

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